Journal
JOURNAL OF VIROLOGY
Volume 89, Issue 3, Pages 1925-1931Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.02262-14
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Funding
- NIH [K22-A99184, P20-GM103625]
- University of Arkansas for Medical Sciences (UAMS)
- [R01-AI080607]
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We show that SAMD9 is an innate host antiviral stress response element that participates in the formation of antiviral granules. Poxviruses, myxoma virus and vaccinia virus specifically, utilize a virus-encoded host range factor(s), such as a member of the C7L superfamily, to antagonize SAMD9 to prevent granule formation in a eukaryotic initiation factor 2 alpha (eIF2 alpha)-independent manner. When SAMD9 is stimulated due to failure of the viral antagonism during infection, the resulting antiviral granules exhibit properties different from those of the canonical stress granules.
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