Journal
JOURNAL OF VIROLOGY
Volume 88, Issue 22, Pages 13231-13239Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.02203-14
Keywords
-
Categories
Funding
- NIH, National Institutes of Health (NIH)-NSF Ecology of Infectious Diseases program [TW009237]
- United Kingdom Economic and Social Research Council
- Wisconsin Partnership Program through the Wisconsin Center for Infectious Diseases
- NIH [R01 AI077376-01]
- Office of Research Infrastructure Programs (ORIP) [P51 RR000167]
- Research Facilities Improvement Program [RR15459-01, RR020141-01]
- National Center for Research Resources [P51 RR013986]
- Office of Research Infrastructure Programs/OD [P51 OD011133]
- NSF [BNS8303506, ISS-1162037]
- University of Wisconsin's Medical Scientist Training Program (MSTP) [T32GM008692]
- National Research Service Award (NRSA) through the Cell and Molecular Pathology (CMP) training program at the University of Wisconsin [T32 GM081061]
- Battelle's prime
- NIAID [HHSN272200700016I]
- University of Wisconsin, Department of Pathology and Laboratory Medicine
- WNPRC
Ask authors/readers for more resources
Since the 1960s, simian hemorrhagic fever virus ( SHFV; Nidovirales, Arteriviridae) has caused highly fatal outbreaks of viral hemorrhagic fever in captive Asian macaque colonies. However, the source(s) of these outbreaks and the natural reservoir(s) of this virus remain obscure. Here we report the identification of two novel, highly divergent simian arteriviruses related to SHFV, Mikumi yellow baboon virus 1 (MYBV-1) and Southwest baboon virus 1 (SWBV-1), in wild and captive baboons, respectively, and demonstrate the recent transmission of SWBV-1 among captive baboons. These findings extend our knowledge of the genetic and geographic diversity of the simian arteriviruses, identify baboons as a natural host of these viruses, and provide further evidence that baboons may have played a role in previous outbreaks of simian hemorrhagic fever in macaques, as has long been suspected. This knowledge should aid in the prevention of disease outbreaks in captive macaques and supports the growing body of evidence that suggests that simian arterivirus infections are common in Old World monkeys of many different species throughout Africa. IMPORTANCE Historically, the emergence of primate viruses both in humans and in other primate species has caused devastating outbreaks of disease. One strategy for preventing the emergence of novel primate pathogens is to identify microbes with the potential for cross-species transmission in their natural state within reservoir species from which they might emerge. Here, we detail the discovery and characterization of two related simian members of the Arteriviridae family that have a history of disease emergence and host switching. Our results expand the phylogenetic and geographic range of the simian arteriviruses and define baboons as a natural host for these viruses. Our findings also identify a potential threat to captive macaque colonies by showing that simian arteriviruses are actively circulating in captive baboons.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available