Journal
JOURNAL OF VIROLOGY
Volume 88, Issue 18, Pages 10995-10999Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.01007-14
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- Institute of Human Infections and Immunity at UTMB
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Machupo virus (MACV) is the etiologic agent of Bolivian hemorrhagic fever (BHF). Utilizing a reverse-genetics system recently developed, we report the rescue of a rationally modified recombinant MACV containing a single mutation in the transmembrane region of the glycoprotein. Following challenge of susceptible mice, we identified a significant reduction in virulence in the novel virus. We also identified an instability leading to reversion of the single mutation to a wild-type genotype.
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