Journal
JOURNAL OF VIROLOGY
Volume 88, Issue 9, Pages 5171-5176Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.03655-13
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Funding
- NIH [R01 AI069317]
- PSWRCE [U54 AI065359]
- UCLA [T32-AI07323]
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Recent evidence identified multiple Henipavirus species in Africa distinct from those in Southeast Asia and Australia. The reported fusion glycoprotein (F) sequence of the African Gh-M74a strain (GhV-F) is likely incorrect: a single base pair deletion near the N terminus results in multiple aberrancies. Rectifying this by adding single nucleotide insertions results in a GhV-F that now possesses a signal peptide, is efficiently cell surface expressed, exhibits syncytium formation when coexpressed with GhV-G protein, and mediates pseudotyped viral particle entry.
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