Journal
JOURNAL OF VIROLOGY
Volume 88, Issue 23, Pages 13897-13909Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.01887-14
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Funding
- World Health Organization (WHO) in Cambodia
- Food and Agriculture Organization (FAO) in Cambodia
- Office of the Assistant Secretary for Preparedness and Response within the U.S. Department of Health and Human Services
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Human infections with influenza A(H5N1) virus in Cambodia increased sharply during 2013. Molecular characterization of viruses detected in clinical specimens from human cases revealed the presence of mutations associated with the alteration of receptor-binding specificity (K189R, Q222L) and respiratory droplet transmission in ferrets (N220K with Q222L). Discovery of quasispecies at position 222 (Q/L), in addition to the absence of the mutations in poultry/environmental samples, suggested that the mutations occurred during human infection and did not transmit further.
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