Journal
JOURNAL OF VIROLOGY
Volume 89, Issue 2, Pages 1468-1473Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.02293-14
Keywords
-
Categories
Funding
- National BioResource Project of the Ministry of Education, Culture, Sports, Science and Technology of Japan (MEXT)
- MEXT
- Ministry of Health, Labor and Welfare of Japan
- Grants-in-Aid for Scientific Research [24390116] Funding Source: KAKEN
Ask authors/readers for more resources
Toll-like receptor 7 and Myd88 are required for antiretroviral antibody and germinal center responses, but whether somatic hypermutation and class-switch recombination are required for antiretroviral immunity has not been examined. Mice deficient in activation-induced cytidine deaminase (AID) resisted Friend virus infection, produced virus-neutralizing antibodies, and controlled viremia. Passive transfer demonstrated that immune IgM from AID-deficient mice contributes to Friend virus control in the presence of virus-specific CD4(+) T cells.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available