Journal
JOURNAL OF VIROLOGY
Volume 88, Issue 21, Pages 12910-12914Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.02107-14
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Funding
- Canadian Institutes of Health Research
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Nuclear factor of activated T cell (NFAT) proteins are key regulators involved in multiple physiological mechanisms, such as immune response and cell growth. The capacity of selective calcineurin/NFAT inhibitors to decrease NFAT-dependent cancer cell progression, particularly in breast cancer, has already been demonstrated. In this study, we report a role for the human herpesvirus 6B (HHV-6B) U54 tegument protein in inhibiting MCF-7 breast cancer cell proliferation by inhibiting NFAT activation.
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