Journal
JOURNAL OF VIROLOGY
Volume 88, Issue 23, Pages 13910-13917Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.02083-14
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Funding
- Agence Nationale de Recherches sur le SIDA et les hepatites (ANRS, Paris, France)
- Vaccine Research Center, NIAID, NIH
- Region Centre and Sidaction (France)
- ANRS
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Extending our previous analyses to the most recently described monoclonal broadly neutralizing antibodies (bNAbs), we confirmed a drift of HIV-1 clade B variants over 2 decades toward higher resistance to bNAbs targeting almost all the identified gp120-neutralizing epitopes. In contrast, the sensitivity to bNAbs targeting the gp41 membrane-proximal external region remained stable, suggesting a selective pressure on gp120 preferentially. Despite this evolution, selected combinations of bNAbs remain capable of neutralizing efficiently most of the circulating variants.
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