Journal
JOURNAL OF VIROLOGY
Volume 89, Issue 5, Pages 2956-2961Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.02721-14
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Funding
- NIH [R01-AI079043, U19-AI088778]
- Swiss National Science Foundation
- Swiss Foundation for Grants in Biology and Medicine SFGBM [PASMP3_145759]
- Swiss National Science Foundation (SNF) [PASMP3_145759] Funding Source: Swiss National Science Foundation (SNF)
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In this study, we show that replication-competent subgenomic hepatitis C virus (HCV) RNA can be transferred to permissive Huh7 cells, leading to the establishment of viral RNA replication. Further, we show that these events are mediated by exosomes rather than infectious virus particles. If similar events occur in vivo, this could represent a novel, albeit inefficient, mechanism of viral spread and immune escape.
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