Journal
JOURNAL OF VIROLOGY
Volume 88, Issue 18, Pages 10986-10989Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.01077-14
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Funding
- State of Pennsylvania Department of Health CURE funds
- NIAID of the National Institutes of Health [1R01AI113047]
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Prior to serological testing, influenza viruses are typically propagated in eggs or cell culture. Recent human H3N2 strains bind to cells with low avidity. Here, we isolated nine primary H3N2 viral isolates from respiratory secretions of children. Upon propagation in vitro, five of these isolates acquired hemagglutinin or neuraminidase mutations that increased virus binding to cell surfaces. These mutations can potentially confound serological assays commonly used to identify antigenically novel influenza viruses.
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