Journal
JOURNAL OF VIROLOGY
Volume 87, Issue 22, Pages 12489-12495Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.01845-13
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Funding
- European Union [223498]
- ANTIGONE [278976]
- German Research Foundation (DFG) [DR 772/3-1, MU3564/1-1]
- German Ministry of Education and Research (BMBF SARS II) [01KI1005A]
- DFG [BA3544/1-1, SFB 704]
- [01KI0705]
- [We 2616/7-1]
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Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe acute respiratory infection with as yet unclear epidemiology. We previously showed that MERS-CoV counteracts parts of the innate immune response in human bronchiolar cells. Here we analyzed accessory proteins 3, 4a, 4b, and 5 for their abilities to inhibit the type I interferon response. Accessory protein 4a was found to block interferon induction at the level of melanoma differentiation-associated protein 5 (MDA5) activation presumably by direct interaction with double-stranded RNA.
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