Journal
JOURNAL OF VIROLOGY
Volume 87, Issue 13, Pages 7700-7707Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.00197-13
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Funding
- BMRC [R-913-300-019-304]
- NRF [R-913-301-015-281]
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Dengue virus is a major human pathogen that has four serotypes (DENV1 to -4). Here we report the cryoelectron microscopy (cryo-EM) structures of immature and mature DENV1 at 6- and 4.5-angstrom resolution, respectively. The subnanometer-resolution maps allow accurate placement of all of the surface proteins. Although the immature and mature viruses showed vastly different surface protein organizations, the envelope protein transmembrane (E-TM) regions remain in similar positions. The pivotal role of the E-TM regions leads to the identification of the start and end positions of all surface proteins during maturation.
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