Journal
JOURNAL OF VIROLOGY
Volume 88, Issue 3, Pages 1843-1848Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.03251-13
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Funding
- National Institutes of Health [CA14779, DE19085]
- American Cancer Society Research Scholar Grant [RSG-13-383-01-MPC]
- Department of Defense [W81XWH1110575]
- Cancer Center Support Grant [P30 CA93373]
- U.S. Department of Defense (DOD) [W81XWH1110575] Funding Source: U.S. Department of Defense (DOD)
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Latent Kaposi's sarcoma-associated herpesvirus (KSHV) episomes are coated with viral latency-associated nuclear antigen (LANA). In contrast, LANA rapidly disassociates from episomes during reactivation. Lytic KSHV expresses polyadenylated nuclear RNA (PAN RNA), a long noncoding RNA (lncRNA). We report that PAN RNA promotes LANA-episome disassociation through an interaction with LANA which facilitates LANA sequestration away from KSHV episomes during reactivation. These findings suggest that KSHV may have evolved an RNA aptamer to regulate latent protein function.
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