Journal
JOURNAL OF VIROLOGY
Volume 87, Issue 9, Pages 5300-5304Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.03496-12
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Funding
- Deutsches Zentrum fur Infektionsforschung (DZIF) from the Bundesministerium fur Bildung und Forschung (BMBF)
- Forschungsforderung gem [47/2012 MR]
- European Union [278433PREDEMICS]
- [01 KI 0705]
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Infections with human coronavirus EMC (HCoV-EMC) are associated with severe pneumonia. We demonstrate that HCoV-EMC resembles severe acute respiratory syndrome coronavirus (SARS-CoV) in productively infecting primary and continuous cells of the human airways and in preventing the induction of interferon regulatory factor 3 (IRF-3)-mediated antiviral alpha/beta interferon (IFN-alpha/beta) responses. However, HCoV-EMC was markedly more sensitive to the antiviral state established by ectopic IFN. Thus, HCoV-EMC can utilize a broad range of human cell substrates and suppress IFN induction, but it does not reach the IFN resistance of SARS-CoV.
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