Journal
JOURNAL OF VIROLOGY
Volume 87, Issue 14, Pages 8261-8265Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.00989-13
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Funding
- National Health and Medical Research Council Australia [1003244, 1002486]
- Australian Research Council [DP110101749]
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Immune evasion by rabies virus depends on targeting of the signal transducers and activator of transcription 1 (STAT1) and STAT2 proteins by the viral interferon antagonist P protein, but targeting of other STAT proteins has not been investigated. Here, we find that P protein associates with activated STAT3 and inhibits STAT3 nuclear accumulation and Gp130-dependent signaling. This is the first report of STAT3 targeting by the interferon antagonist of a virus other than a paramyxovirus, indicating that STAT3 antagonism is important to a range of human-pathogenic viruses.
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