Journal
JOURNAL OF VIROLOGY
Volume 87, Issue 17, Pages 9953-9958Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.01562-13
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Funding
- [R01AI098775-01-PIs]
- [CON21152]
- Grants-in-Aid for Scientific Research [24659401] Funding Source: KAKEN
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The newly emerged Middle East respiratory syndrome coronavirus (MERS-CoV) infects human bronchial epithelial Calu-3 cells. Unlike severe acute respiratory syndrome (SARS)-CoV, which exclusively infects and releases through the apical route, this virus can do so through either side of polarized Calu-3 cells. Infection results in profound apoptosis within 24 h irrespective of its production of titers that are lower than those of SARS-CoV. Together, our results provide new insights into the dissemination and pathogenesis of MERS-CoV and may indicate that the virus differs markedly from SARS-CoV.
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