Journal
PROGRESS IN NEUROBIOLOGY
Volume 126, Issue -, Pages 19-35Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pneurobio.2014.12.002
Keywords
Plasticity; Active dendrites; Associative memory; Synapse clustering; Synaptic tagging and capture
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Funding
- National Institutes of Health [R37-AG13622, P50-MH0779720, 1F32MH097413]
- European Research Council Starting Grant dEMORY [GA 311435]
- BIOSYS project, Action KRIPIS of the General Secretariat for Research and Technology Ministry of Education, Greece [MIS-448301, 2013SE01380036]
- European Regional Development Fund (Sectoral Operational Program: Competitiveness and Entrepreneurship, NSRF)/European Commission
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It is generally accepted that complex memories are stored in distributed representations throughout the brain, however the mechanisms underlying these representations are not understood. Here, we review recent findings regarding the subcellular mechanisms implicated in memory formation, which provide evidence for a dendrite-centered theory of memory. Plasticity-related phenomena which affect synaptic properties, such as synaptic tagging and capture, synaptic clustering, branch strength potentiation and spinogenesis provide the foundation for a model of memory storage that relies heavily on processes operating at the dendrite level. The emerging picture suggests that clusters of functionally related synapses may serve as key computational and memory storage units in the brain. We discuss both experimental evidence and theoretical models that support this hypothesis and explore its advantages for neuronal function. (C) 2015 Elsevier Ltd. All rights reserved.
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