Journal
JOURNAL OF VIROLOGY
Volume 87, Issue 10, Pages 6037-6043Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.00153-13
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- NCI
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Human papillomaviruses (HPVs) modulate expression of host microRNAs. Our deep-sequencing analysis of organotypic raft cultures identified microRNA 145 (miR-145) as a differentiation-dependent microRNA that has functionally active target sequences in the HPV-31 E1 and E2 open reading frames. Overexpression of miR-145 in HPV-positive cells resulted in reduced genome amplification and late gene expression, along with decreased levels of cellular transcription factor KLF-4. Our studies show that HPV modulates miR-145 expression to control its own life cycle.
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