Journal
JOURNAL OF VIROLOGY
Volume 87, Issue 20, Pages 11287-11291Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.01429-13
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- Deutsche Forschungsgemeinschaft [KFO 183]
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Dendritic cells play a central role in the immune control of human cytomegalovirus (HCMV) infection. This work aimed at investigating the impact of noninfectious, subviral dense bodies of HCMV on the maturation and activation of dendritic cells (DC). Treatment of immature DC with dense bodies led to the maturation of these cells and significantly increased their capacity for cytokine release and antigen presentation. Dense body-activated DC may thereby contribute to the development of antiviral immunity.
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