Journal
PROGRESS IN NEUROBIOLOGY
Volume 133, Issue -, Pages 1-26Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pneurobio.2015.07.004
Keywords
Amyotrophic lateral sclerosis; Motoneurons disease; Neurodegeneration; Neuromuscular junction; Neuroprotection
Categories
Funding
- CIBERNED
- TERCEL
- Instituto de Salud Carlos III of Spain
- Fundacio La Marato-TV3, Catalunya, Spain [TV3201428-10]
- Ministerio de Educacion of Spain
Ask authors/readers for more resources
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive degeneration of upper and lower motoneurons, leading to muscle weakness and paralysis, and finally death. Considerable recent advances have been made in basic research and preclinical therapeutic attempts using experimental models, leading to increasing clinical and translational research in the context of this disease. In this review we aim to summarize the most relevant findings from a variety of aspects about ALS, including evaluation methods, animal models, pathophysiology, and clinical findings, with particular emphasis in understanding the role of every contributing mechanism to the disease for elucidating the causes underlying degeneration of motoneurons and the development of new therapeutic strategies. (C) 2015 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available