Journal
PROGRESS IN NEUROBIOLOGY
Volume 134, Issue -, Pages 122-139Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pneurobio.2015.09.006
Keywords
ncRNAs; Brain injury; Spinal cord injury; Peripheral nerve injury; Post-transcriptional regulation
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Funding
- National Key Basic Research Program of China [2014CB542202]
- 863 Program [2012AA020502]
- National Natural Science Foundation of China [81130080, 31100761, 31200799, 31371062]
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
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Non-coding RNAs (ncRNAs), especially microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), have attracted much attention since their regulatory roles in diverse cell processes were recognized. Emerging studies demonstrate that many ncRNAs are differentially expressed after injury to the nervous system, significantly affecting nerve regeneration. In this review, we compile the miRNAs and lncRNAs that have been reported to be dysregulated following a variety of central and peripheral nerve injuries, including acquired brain injury, spinal cord injury, and peripheral nerve injury. We also list investigations on how these miRNAs and lncRNAs exert the regulatory actions in neurodegenerative and neuroregenerative processes through different mechanisms involving their interaction with target coding genes. We believe that comprehension of the expression profiles and the possible functions of ncRNAs during the processes of nerve injury and regeneration will help understand the molecular mechanisms responsible for post-nerve-injury changes, and may contribute to the potential use of ncRNAs as a diagnostic marker and therapeutic target for nerve injury. (C) 2015 Elsevier Ltd. All rights reserved.
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