Journal
JOURNAL OF VIROLOGY
Volume 87, Issue 24, Pages 13930-13935Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.02701-13
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Funding
- NIAID [HHSN272200700016I]
- Joint Science and Technology Office for Chemical and Biological Defense [TMTI0048_09_RD_T]
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Ocozocoautla de Espinosa virus (OCEV) is a novel, uncultured arenavirus. We found that the OCEV glycoprotein mediates entry into grivet and bat cells through transferrin receptor 1 (TfR1) binding but that OCEV glycoprotein precursor (GPC)-pseudotyped retroviruses poorly entered 53 human cancer cell lines. Interestingly, OCEV and Tacaribe virus could use bat, but not human, TfR1. Replacing three human TfR1 amino acids with their bat ortholog counterparts transformed human TfR1 into an efficient OCEV and Tacaribe virus receptor.
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