Journal
JOURNAL OF VIROLOGY
Volume 87, Issue 23, Pages 13053-13058Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.02220-13
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Funding
- Scottish Funding Council
- University of St Andrews
- Wellcome Trust
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The induction of an interferon-induced antiviral state is a powerful cellular response against viral infection that limits viral spread. Here, we show that a preexisting antiviral state inhibits the replication of influenza A viruses in human A549 cells by preventing transport of the viral genome to the nucleus and that the interferon-induced MxA protein is necessary but not
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