Journal
JOURNAL OF VIROLOGY
Volume 87, Issue 12, Pages 7160-7165Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.00526-13
Keywords
-
Categories
Funding
- Deutsche Forschungsgemeinschaft
- Hector Foundation
Ask authors/readers for more resources
It has been reported that HIV-1 Vpu mediates the degradation of interferon regulatory factor 3 (IRF-3) to avoid innate immune sensing. Here, we show that Vpu does not deplete IRF-3 from transfected cell lines or HIV-1-infected primary cells. Furthermore, the Vpu-dependent suppression of beta interferon expression described in previous studies could be ascribed to inhibition of NF-kappa B activation. Thus, Vpu suppresses innate immune activation through inhibition of NF-kappa B rather than degradation of IRF-3.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available