Journal
JOURNAL OF VIROLOGY
Volume 88, Issue 3, Pages 1834-1838Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.02935-13
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Funding
- CEIRS (NIAID/NIH) [HHSN266200700010C]
- European Union [223498]
- ANTIGONE [278976]
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Middle East respiratory syndrome coronavirus (MERS-CoV) replicates in cells of different species using dipeptidyl peptidase 4 (DPP4) as a functional receptor. Here we show the resistance of ferrets to MERS-CoV infection and inability of ferret DDP4 to bind MERS-CoV. Site-directed mutagenesis of amino acids variable in ferret DPP4 thus revealed the functional human DPP4 virus binding site. Adenosine deaminase (ADA), a DPP4 binding protein, competed for virus binding, acting as a natural antagonist for MERS-CoV infection.
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