Journal
JOURNAL OF VIROLOGY
Volume 86, Issue 9, Pages 5390-5392Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.00040-12
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Maintenance of HIV latency in vitro has been linked to methylation of HIV DNA. However, examinations of the degree of methylation of HIV DNA in the latently infected, resting CD4(+) T cells of infected individuals receiving antiretroviral therapy have been limited. Here, we show that methylation of the HIV 5' long terminal repeat (LTR) in the latent viral reservoir of HIV-infected aviremic individuals receiving therapy is rare, suggesting that other mechanisms are likely involved in the persistence of viral latency.
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