Journal
JOURNAL OF VIROLOGY
Volume 86, Issue 10, Pages 5922-5925Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.07060-11
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Funding
- National Health and Medical Research Council of Australia [509281, 567122]
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The interaction between influenza virus and dendritic cells (DCs) remains poorly defined and controversial. Here we show that influenza virus replication in mouse bone marrow-derived DCs is abortive, despite viral genome transcription and replication occurring for each gene segment and viral hemagglutinin and nucleoprotein, at least, being produced. Electron microscopy reveals that virus assembly, rather than release of virus from the cell surface, is defective.
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