Journal
JOURNAL OF VIROLOGY
Volume 87, Issue 3, Pages 1916-1918Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.02980-12
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Funding
- NIAID [HHSN272201000054C, HHSN266200700010C]
- Center for Research on Influenza Pathogenesis (CRIP)
- NIAID Mucosal Immunity Study Team (MIST) Program [U01AI095611]
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We show that influenza A H1N1 virus infection leads to very low infectivity in mouse dendritic cells (DCs) in vitro compared with that in human DCs. This holds when H3 or H5 replaces H1 in recombinant viruses. Viruslike particles confirm the difference between mouse and human, suggesting that reduced virus entry contributes to lower mouse DC infectivity. Low infectivity of mouse DCs should be considered when they are used to study responses of DCs that are actually infected.
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