Journal
JOURNAL OF VIROLOGY
Volume 87, Issue 3, Pages 1890-1892Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.02852-12
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Funding
- NIH/NIAID [HHSN272201000009I]
- Prion Research Institute
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While the facile transmission of chronic wasting disease (CWD) remains incompletely elucidated, studies in rodents suggest that exposure of the respiratory mucosa may be an efficient pathway. The present study was designed to address this question in the native cervid host. Here, we demonstrate aerosol transmission of CWD to deer with a prion dose > 20-fold lower than that used in previous oral inoculations. Inhalation of prions may facilitate transmission of CWD and, perhaps, other prion infections.
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