Journal
JOURNAL OF VIROLOGY
Volume 86, Issue 19, Pages 10873-10879Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.01506-12
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Funding
- European Community [261466]
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Chikungunya virus nonstructural protein nsP3 has an essential but unknown role in alphavirus replication and interacts with Ras-GAP SH3 domain-binding protein (G3BP). Here we describe the first known function of nsP3, to inhibit stress granule assembly by recruiting G3BP into cytoplasmic foci. A conserved SH3 domain-binding motif in nsP3 is essential for both nsP3-G3BP interactions and viral RNA replication. This study reveals a novel role for nsP3 as a regulator of the cellular stress response.
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