Journal
JOURNAL OF VIROLOGY
Volume 86, Issue 19, Pages 10862-10865Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.00928-12
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Funding
- National Institutes of Health [AI066305, AI066924, AI078526, AI095985]
- Bill and Melinda Gates Foundation
- Ragon Institute of MGH, MIT, and Harvard
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The cellular receptor utilized by adenovirus serotype 26 (Ad26) has remained unclear. Here we show that Ad26 transduction is CD46-dependent and is efficiently blocked by anti-CD46 but not anti-CAR antibodies, demonstrating that Ad26 utilizes CD46 as a primary cellular receptor. Moreover, following Ad26 vaccination of rhesus monkeys, we did not observe sustained activation of peripheral or mucosal vector-specific CD4(+) T lymphocytes. These data contribute to our understanding of Ad26 as a candidate vaccine vector.
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