Journal
JOURNAL OF VIROLOGY
Volume 86, Issue 24, Pages 13795-13799Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.02174-12
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Funding
- Intramural Research Program of NIAID, NIH
- Division of Intramural Research, NIAID, NIH
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Simian immunodeficiency virus (SIV) infection of macaques can result in central nervous system disorders, such as meningitis and encephalitis. We studied 10 animals inoculated with brain-derived virus from animals with SIV encephalitis. Over half of the macaques developed SIV-induced neurologic disease. Elevated levels of systemic immune activation were observed to correlate with viral RNA in the cerebral spinal fluid but not with plasma viral load, consistent with a role for SIV in the pathogenesis of neurologic disease.
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