Journal
JOURNAL OF VIROLOGY
Volume 87, Issue 5, Pages 2963-2968Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.02688-12
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Funding
- National Basic Research Program (973 Program) [2011CB504702]
- China Postdoctoral Science Foundation [2012T50165]
- Graduate Innovation Foundation of China Agricultural University [2012YJ069]
- National Natural Science Foundation of China [31272535]
- Innovative Research Group of the National Natural Science of Foundation of China [81021003]
- Taishan Scholar Foundation
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H9N2 influenza viruses with an A316S substitution in hemagglutinin (HA) and a shorter neuraminidase (NA) stalk have become predominant in China. The A316S was shown to increase HA cleavage efficiency when combined with short stalk NA, and the short stalk NA improved NA enzyme activity and release of virus from erythrocytes. Single mutations or combinations of these mutations strengthened the virulence of H9N2 virus in chickens and mice.
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