Journal
JOURNAL OF VIROLOGY
Volume 86, Issue 24, Pages 13263-13271Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.00565-12
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Funding
- CNPq [302987/2008-8, 301641/2010-2]
- CNPq/CAPES/FAPESPA [573739/2008-0]
- National Institutes of Health [AI57158]
- USAID Predict
- Defense Threat Reduction Agency
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Globally, yellow fever virus infects nearly 200,000 people, leading to 30,000 deaths annually. Although the virus is endemic to Latin America, only a single genome from this region has been sequenced. Here, we report 12 Brazilian yellow fever virus complete genomes, their genetic traits, phylogenetic characterization, and phylogeographic dynamics. Variable 3' noncoding region (3' NCR) patterns and specific mutations throughout the open reading frame altered predicted secondary structures. Our findings suggest that whereas the introduction of yellow fever virus in Brazil led to genotype I-predominant dispersal throughout South and Central Americas, genotype II remained confined to Bolivia, Peru, and the western Brazilian Amazon.
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