Journal
JOURNAL OF VIROLOGY
Volume 86, Issue 21, Pages 11926-11930Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.01430-12
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Funding
- PHS from the NIH [AI061382]
- ARRA [AI061382-S4]
- NIH-NCRR [1S10RR023454-01]
- NIH-NCI [1U54CA143868-01]
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Self-assembly of Kaposi's sarcoma-associated herpesvirus capsids occurs when six proteins are coexpressed in insect cells using recombinant baculoviruses; however, if the small capsid protein (SCP) is omitted from the coinfection, assembly does not occur. Herein we delineate and identify precisely the assembly domain and the residues of SCP required for assembly. Hence, six residues, R14, D18, V25, R46, G66, and R70 in the assembly domain, when changed to alanine, completely abolish or reduce capsid assembly.
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