Journal
JOURNAL OF VIROLOGY
Volume 86, Issue 18, Pages 10218-10220Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.00353-12
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Funding
- National Institute of Allergy and Infectious Diseases [R01 AI052778, U19 AI076981]
- La Jolla Foundation for Microbicide Research
- Mintaka Foundation
- James B. Pendleton Charitable Trust
- CONRAD
- World Health Organization
- International Partnership for Microbicides
- INSERM
- Ensemble contre le SIDA-SIDACTION
- French National Agency for Research on AIDS (ANRS)
- Swiss National Science Foundation
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CCR5 is the major HIV-1 entry coreceptor. RANTFS/CCL5 analogs are more potent inhibitors of infection than native chemokines; one class activates and internalizes CCR5, one neither activates nor internalizes, and a third partially internalizes without activation. Here we show that mutations in CCR5 transmembrane domains differentially impact the activity of these three inhibitor classes, suggesting that the transmembrane region of CCR5, a key interaction site for inhibitors, is a sensitive molecular switch, modulating receptor activity.
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