Journal
JOURNAL OF VIROLOGY
Volume 86, Issue 6, Pages 3386-3388Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.06909-11
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Funding
- Spanish Ministerio de Ciencia e Innovacion [BFU2009-06993]
- Human Frontier Science Program Organization [RGP12/2008]
- Generalitat Valenciana [PROMETEO2010/019]
- CSIC [2010TW0015]
- U.S. National Institutes of Health [R01GM079843-01]
- ARRA PDS [35063]
- EC [FP7231807]
- Universidad Politenica de Valencia
- CSIC JAE
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A potential drawback of recent antiviral therapies based on the transgenic expression of artificial microRNAs is the ease with which viruses may generate escape mutations. Using a variation of the classic Luria-Delbruck fluctuation assay, we estimated that the spontaneous mutation rate in the artificial microRNA (amiR) target of a plant virus was ca.6 x 10(-5) per replication event.
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