Journal
JOURNAL OF VIROLOGY
Volume 86, Issue 22, Pages 12417-12421Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.00967-12
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Funding
- NIAID NIH HHS [R01 AI091476] Funding Source: Medline
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A tyrosine-sulfated CCR5-mimetic peptide, CCR5mim1, inhibits HIV-1 infection more efficiently than sulfopeptides based on the CCR5 amino terminus. Here we characterized sulfopeptide chimeras of CCR5mim1 and the heavy-chain CDR3 of the antibody PG16. Two chimeras bound a range of envelope glycoproteins and neutralized HIV-1 more efficiently than CCR5mim1. An immunoadhesin form of one of these, CCR5mim2-Ig, synergized with CD4-Ig to neutralize HIV-1. These sulfopeptides are among the broadest and most potent CCR5-mimetic peptides described to date.
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