Journal
JOURNAL OF VIROLOGY
Volume 87, Issue 5, Pages 2979-2982Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.03181-12
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Funding
- National Institutes of Health [AG032958, AG06127]
- National Center for Research and Resources [2M01RR005096, 1G20RR016930, 1G20RR018397, 1G20RR019628, 1G20RR013466, 1G20RR012112, 1G20RR015169, P51 RR00164-50]
- Office of Research Infrastructure Programs (ORIP) of the National Institutes of Health
- Virgo Consortium
- Dutch government [FES0908]
- Netherlands Genomics Initiative (NGI) [050-060-452]
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Ganglia of monkeys with reactivated simian varicella virus (SVV) contained more CD8 than CD4 T cells around neurons. The abundance of CD8 T cells was greater less than 2 months after reactivation than that at later times and correlated with that of CXCL10 RNA but not with those of SVV protein or open reading frame 61 (ORF61) antisense RNA. CXCL10 RNA colocalized with T-cell clusters. After SVV reactivation, transient T-cell infiltration, possibly mediated by CXCL10, parallels varicella zoster virus (VZV) reactivation in humans.
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