Journal
JOURNAL OF VIROLOGY
Volume 86, Issue 14, Pages 7699-7703Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.00804-12
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Funding
- ICGEB
- Department of Science and Technology of the Republic of South Africa
- International Atomic Energy Agency [RAF/6/029]
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We studied neutralization of CRF02_AG HIV-1-infected plasma samples. In contrast to previous reports, these samples neutralized CRF02_AG viruses better than other viruses. This included six of eight CRF02_AG viruses previously designated resistant (tier 2/3 or 3). Only viruses 253-11 and 278-50 remained highly resistant, but they were sensitive to membrane-proximal external region (MPER)-specific monoclonal antibodies, suggesting neutralization targets for even these viruses. We propose using high-neutralizing-within-subtype samples for evaluation of neutralization resistance of viruses.
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