Journal
JOURNAL OF VIROLOGY
Volume 87, Issue 2, Pages 1278-1284Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.02597-12
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Funding
- Wellcome Trust [089870/Z/09/Z]
- European Union
- Medical Research Council [G0600006] Funding Source: researchfish
- MRC [G0600006] Funding Source: UKRI
- Wellcome Trust [089870/Z/09/Z] Funding Source: Wellcome Trust
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Avian-origin influenza virus polymerase activity can be dramatically increased in human cells with the PB2 E627K mutation. Previously, others have proposed that this mutation increases the stability of the viral ribonucleoprotein complex (vRNP) measured by the interaction between PB2 and NP. However, we demonstrate here that a variety of PB2 adaptive mutations, including E627K, do not enhance the stability of the vRNP but rather increase the amount of replicated RNA that results in more PB2-NP coprecipitation.
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