Journal
JOURNAL OF VIROLOGY
Volume 87, Issue 4, Pages 2348-2351Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.01742-12
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Funding
- NIH [R01CA069943, R01AI076274]
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MicroRNAs are key regulators of the immune response, but their role in CD8 T cell differentiation in vivo is not known. We show that miR-155 is important in both effector and memory antiviral CD8 T cell responses. Without miR-155, there was a weaker effector response and a skewing toward memory precursor cells. At the memory stage, miR-155-deficient CD8 T cells preferentially differentiated into central memory cells and were capable of mounting a potent secondary response.
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