Journal
JOURNAL OF VIROLOGY
Volume 86, Issue 5, Pages 2856-2858Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.06882-11
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Funding
- NIH [R01AI089728]
- University of Minnesota AHC Faculty
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Among different coronavirus genera, the receptor-binding S1 subunits of their spike proteins differ in primary, secondary, and tertiary structures. This study identified shared structural topologies (connectivity of secondary structural elements) in S1 domains of different coronavirus genera. The results suggest that coronavirus S1 subunits share a common evolutionary origin but have attained diverse sequences and structures following extensive divergent evolution. The results also increase understanding of the structures and functions of coronavirus SI domains whose tertiary structures are currently unknown.
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