Journal
JOURNAL OF VIROLOGY
Volume 85, Issue 24, Pages 13448-13452Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.00775-11
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Funding
- United Kingdom Medical Research Council
- National Institutes of Health [AI070072]
- European Community [FP7/2007-2013, PIEF-GA-2009-237501]
- Department of Health via a National Institute for Health Research comprehensive Biomedical Research Centre
- St. Thomas' NHS Foundation Trust in partnership with King's College London and King's College Hospital NHS Foundation Trust
- MRC [G1000196, G0401570, G1001081] Funding Source: UKRI
- Medical Research Council [G1000196, G0401570, G1001081] Funding Source: researchfish
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Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3 (APOBEC3) proteins are encapsidated by assembling HIV-1 virions and edit viral cDNA in the next round of infection. Using alpha interferon (IFN-alpha)-treated monocyte-derived macrophages, we show that infrequent editing of HIV-1 reverse transcripts can also be mediated by APOBEC3 proteins supplied by the targets of infection. Based on the local sequence contexts of these mutations and the established characteristics of APOBEC3 protein expression in myeloid cells, we speculate that APOBEC3A may be responsible for a substantial proportion of this activity.
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