Journal
JOURNAL OF VIROLOGY
Volume 86, Issue 4, Pages 2176-2187Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.06223-11
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Funding
- Proyecto Instituto Milenio [P09/016-F IMII]
- Financiado con Fondos Programa ICM
- PHS [2U01AI045452-11]
- CONICYT [1100756]
- MECESUP-USACH
- CONICYT, Chile
- French Embassy in Chile
- Fondation pour la Recherche Medicale (FRM)
- French Ministry (MENRT)
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The small mRNA (SmRNA) of all Bunyaviridae encodes the nucleocapsid (N) protein. In 4 out of 5 genera in the Bunyaviridae, the smRNA encodes an additional nonstructural protein denominated NSs. In this study, we show that Andes hantavirus (ANDV) SmRNA encodes an NSs protein. Data show that the NSs protein is expressed in the context of an ANDV infection. Additionally, our results suggest that translation initiation from the NSs initiation codon is mediated by ribosomal subunits that have bypassed the upstream N protein initiation codon through a leaky scanning mechanism.
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