Journal
JOURNAL OF VIROLOGY
Volume 86, Issue 1, Pages 599-604Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.06129-11
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Funding
- National Institutes of Health [CA096512, CA124332, CA119889]
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We investigated the role of microtubules in rhesus rhadinovirus (RRV) nuclear trafficking in rhesus fibroblasts. Intact microtubules and microtubule dynamics are required for RRV trafficking to perinuclear regions. RRV trafficking was reduced by an inhibitor of the dynein motor and overexpression of dynamitin. Furthermore, RRV particles are colocalized with microtubules and dynein proteins. These results highlight the important roles of microtubules and dynein-dynactin complexes in the transport of RRV particles to nuclei during primary infection.
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