Journal
JOURNAL OF VIROLOGY
Volume 85, Issue 12, Pages 6091-6095Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.02113-10
Keywords
-
Categories
Funding
- NHMRC [456137, 631401]
- Queensland Health
- [AHA 0665211B]
Ask authors/readers for more resources
The human cytomegalovirus (CMV) proteins US28 and UL33 are homologous to chemokine receptors (CKRs). Knockout of the mouse CMV M33 protein (UL33 homologue) results in substantial attenuation of salivary gland infection/replication and reduced efficiency of reactivation from tissue explants. M33-mediated G protein-coupled signaling is critical for the salivary gland phenotype. In this report, we demonstrate that US28 and (to a lesser degree) UL33 restore reactivation from tissue explants and partially restore replication in salivary glands (compared to a signaling-deficient M33 mutant). These studies provide a novel small animal model for evaluation of therapies targeting the human CMV CKRs.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available