Journal
JOURNAL OF VIROLOGY
Volume 86, Issue 1, Pages 635-636Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.06593-11
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Funding
- U.S. Public Health Service NIH [EY013124, P30EY014104]
- Research to Prevent Blindness, Inc.
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Five genomes of human subspecies B1 adenoviruses isolated from cases of acute respiratory disease have been sequenced and archived for reference. These include representatives of two prevalent genomic variants of HAdV-7, i.e., HAdV-7h and HAdV7d2. The other three are HAdV-3/16, HAdV-16 strain E26, and HAdV-3+7 strain Takeuchi. All are recombinant genomes. Genomics and bioinformatics provide detailed views into the genetic makeup of these pathogens and insight into their molecular evolution. Retrospective characterization of particularly problematic older pathogens such as HAdV-7h (1987) and intriguing isolates such as HAdV-3+7 strain Takeuchi (1958) may provide clues to their phenotypes and serology and may suggest protocols for prevention and treatment.
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