Journal
JOURNAL OF VIROLOGY
Volume 85, Issue 17, Pages 9249-9252Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.00844-11
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Funding
- National Institute of Allergy and Infectious Diseases (NIAID) through the Western Regional Center of Excellence for Biodefense and Emerging Infectious Disease Research [U01AI082202]
- NIAID [R01AI070207]
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Chikungunya virus (CHIKV) is an important pathogen causing outbreaks of highly debilitating and often chronic, arthralgic human disease. We have designed chimeric alphaviruses encoding CHIKV-specific structural proteins but no structural or nonstructural proteins capable of interfering with development of cellular antiviral response. These chimeras demonstrate a highly attenuated phenotype in both immunocompetent and immunocompromised (A129) mice. However, after a single vaccination, they induced protective immune response against subsequent CHIKV challenge, characterized by high titers of neutralizing antibodies. The rational design of alphavirus genomes provides a strong basis for the development of new recombinant alphaviruses with irreversible, highly attenuated, cell type-restricted phenotypes.
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