Journal
JOURNAL OF VIROLOGY
Volume 85, Issue 22, Pages 12062-12066Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.00684-11
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Funding
- Ministerio de Educacion y Ciencia [BFU2008-00448]
- Comunidad de Madrid [S-SAL-0185-2006]
- Ciber de Enfermedades Infecciosas
- Plan Nacional de Investigacion Cientifica
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The influenza A virus polymerase associates with a number of cellular transcription-related factors, including RNA polymerase II. We previously described the interaction of influenza virus polymerase subunit PA with human CLE/C14orf166 protein (hCLE), a positive modulator of this cellular RNA polymerase. Here, we show that hCLE also interacts with the influenza virus polymerase complex and colocalizes with viral ribonucleoproteins. Silencing of hCLE causes reduction of viral polymerase activity, viral RNA transcription and replication, virus titer, and viral particle production. Altogether, these findings indicate that the cellular transcription factor hCLE is an important protein for influenza virus replication.
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